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KMID : 0606320040200010001
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Journal of Phamacetical Sciences Sookmyung Women s University
2004 Volume.20 No. 1 p.1 ~ p.5
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Anti-Angiogenic and Analgesic Effects of Cordyceps scarabaeicola
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Won So-Young
Jung Hyun-Joo
Koo Hye-Jin
Soh Jee-Hyun
Park Eun-Hee
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Abstract
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Dongchunghacho (Dong-Chong-Xia-Cho in Chinese), one of folk medicines, is traditionally believed to be effective against various diseases. It includes many different genera such as Cordyceps, Paecilomyces, Torrubiella and Podonectria. Cordyceps scarabaeicola is one of well-known species. The 70% ethanolic extracts were prepared from two different sources of C. scarabaeicola, fresh fruiting bodies (FFB) and mycelial cultured cells (MCC). Anti-angiogenic activity was determined by the chick embryo chorioallantoic membrane assay. Both FFB and MCC were found to contain strong anti-angiogenic activities. The extracts at the dose of 10 μ g showed anti-angiogenic activity comparable to that of retinoic acid (dose, 1 μg) used as a control agent. Anti-angiogenic activities of FFB and MCC appeared to be concentration-dependent. No significant differences were found between the effects of FFB and MCC. These results might support the plausible anti-tumor activity of C. Scarabaeicola. FFB also contains strong analgesic activity.
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